Endocrine Abstracts

Signaling by TSH receptor (TSHR) was thought to terminate after withdrawal of TSH. Recently, however, TSHR was found to signal persistently even after TSH withdrawal via both the cAMP and inositol-1,4,5-trisphosphate pathways. Similar persistent signaling was found for other G protein-coupled receptors, such as the parathyroid hormone receptor, which stimulates the cAMP pathway, and the S1P1 receptor, which inhibits the cAMP pathway. For TSHR, a controversy has developed as to...